Department of Medicine of the Keck School of. Medicine, University of Southern California
October 18, 1933- June 27, 2008
For over 40 years Dr. John Leedom walked the halls of LAC/USC. He was generally regarded as the most brilliant clinician many have ever known. He trained thousands of the best physicians in America. His former students, residents and fellows practice in every state.
Dr. Leedom was Chief of Infectious Diesease at LAC/USC at the time the AIDS epidemic began. He became Director of the multidisciplinary AIDS Clinic and the AIDS Service, March, 1985. He had a deep compassion for all patients, especially the poor, and those who suffered so much at the beginning of the epidemic. Under his direction, the AIDS Service, tested many of the drugs which have helped to make HIV a survivable infection.
All this is especially remarkable when one considers that when Dr. Leedom graduated from medical school in 1958 the molecular structure of DNA had just been discovered. Many of the tools we now take for granted like CT scanning and MRI had not been thought of. Also, most of the pharmaceuticals we use today had not been developed. His dedication to life long learning made him the outstanding physician scholar that he was. He was quick to embrace new technology and ideas, as you see him here.
CIRRICULUM VITAE
Birthdate: October 18, 1933
Birthplace: Peoria, Illinois
Marital Status: Married
Wife’s Name: Anita J. West
Children: Two
Education
High School: Lockport Township High School
Lockport, Illinois, 1951
University: University of Illinois, B.A., 1955
University of Illinois, B.S., 1956
Medical School: University of Illinois (Honors), M.D., 1958
Internship: D.C. General Hospital, Washington, D.C.
7/1/58-6/30/59
Diplomate: National Board of Medical Examiners, 1959
Residency: University of Illinois Research and Educational Hospital
7/1/59-6/30/60 and 7/1/61-6/30/62
Fellowship: University of Illinois Graduate College Student Research Fellowship, Department of Biochemistry Summer 1955
National Foundation for Poliomyelitis Student Research Fellowship, Department of Biochemistry,
University of Illinois, Summer 1956
University of Illinois Research and EducationalHospitals, July 1, 1960-June 30, 1961
Licensure: California State License,
Illinois State License,
Board Certification: American Board of Internal Medicine
April 7, 1967
Subspecialist in Infectious Diseases
American Board of Internal Medicine
October 15, 1976
Honors: Phi Beta Kappa
Alpha Omega Alpha
M.D. with Honors
Professional Background
Academic Appointments
1. Postdoctorate Research Fellow Infectious Disease
University of Illinois Research and Educational Hospital
July 1, 1960-June 30, 1961
2. Assistant in Medicine, University of Illinois, College of Medicine
July 1, 1959-June 30, 1961
3. Instructor in Medicine, University of Illinois, College of Medicine
July 1, 1961-June 30, 1962
4. Assistant Professor of Medicine, University of Southern California
School of Medicine
September 1962-September 1, 1968
5. Associate Professor of Medicine, University of Southern California
School of Medicine
September 1, 1968-June 30, 1976
6. Professor of Medicine, University of Southern California
School of Medicine
July 1, 1976-December 2002
7. Assistant Attending Physician, Medicine and Communicable Diseases
Los Angeles County General Hospital
September 1962-June 1965
8. Attending Physician, Medicine and Communicable Diseases
Los Angeles County General Hospital
June, 1965-December 2002
9. Attending Physician, Department of Medicine, Wadsworth Veterans
Administration Hospital, Los Angeles
January 1970-1974
10. Chief, First Medical Division, LAC/USC Medical Center
July 1, 1973-1994
11. Chief, Division of Infectious Diseases, LAC/USC Medical Center
July 1, 1975-December 31, 2002
12. Director, Multidisciplinary AIDS Clinic and AIDS Services,
LAC+USC Medical Center, March 1985-December 31, 2002
Committee Appointments
1. Member, Medical Advisory Committee, Tuberculosis and Health
Association of Los Angeles County, July 1966-1972
2. Editor, Current Concepts, Tuberculosis and Health Association of
Los Angeles, July 1966-April 1970
3. Member, Breathmoblie Committee, Tuberculosis and Health Association
Of Los Angeles County, July 1966-April 1969
4. Member, SCOPE, Panel on Infectious Diseases for XVIII Revision,
U.S. Pharmacopeia, 1966 -1970
5. Member, Alumni Committee for Selection of Annual Prize, Epidemic
Intelligence Service, U.S.P.H.S. (NCDC), Atlanta, Georgia,
April 1967-1970
6. Member, Milk Commission of Los Angeles County, May 1969-present
7. Member, Laundry Practices Committee (appointed by the Board of
Supervisors), Los Angeles County, November 1969-1972
8. Member, Committee on Environment and Public Health of Los Angeles
County Medical Association, February 1970-1981
9. Member, Research Subcommittee California Research and Medical Education
Fund, Tuberculosis and Respiratory Disease Association of California,
January 1971-April 1976
10. Chairman, Hospital Infection Committee, General Hospital and Psychiatric
Hospital, LAC-USC Medical Center, December 1974-December 2004
11. Member, Board of Directors, Los Angeles County lung Association
1973-1979
12. Member, House of Delegates, California Lung Association
April 1974-1988
13. Chairman, Medical Records Committee
January 1981-1984
14. Member, Athletic Tickets Subcommittee, USC
July 1982-1984
15. Member, Research Committee, LAC+USC Medical Center
March 1988-present
16. Member, Board of Directors, Salerni Collegium, 1998-present
17. Treasurer, Salerni Collegium, 2000-present
Service
Epidemic Intelligence Service Officer, Communicable Disease Center, Atlanta, Georgia, USPHS, Rank Surg. Lt. Cmdr (R) assigned to the Hastings Foundation Infectious Disease Laboratory. Department of Pediatrics, University of Southern California School of Medicine, July 1, 1962-June 30, 1964. Currently, Captain, inactive reserve, USPHS
Consultantships
1. Los Angeles County Health Department, July 1964-present
2. American Red Cross, Vaccinia Immune Globulin Program
1964-1970
3. HSMA, Health Facilities Planning and Construction Service
Office of the Director, DHEW, Rockville, Maryland, 1969-1974
4. Consultant for the World Health Organization in the investigation and control of poliomyelitis epidemic, Barbados, British West Indies
May 29, 1963-June 17, 1963
5. USPHS, Vaccinia Immune Globulin Program, July 1, 1970-December 2002
6. Member, Task Force for Study on the Efficacy of Nosocomial Infection Control, Center for Disease Control, USPHS, Atlanta, Georgia.
7. Member, Advisory Committee to California State Health Department, complications of smallpox vaccination, 2002-present
Society Memberships
1. Phi Beta Kappa
2. Alpha Omega Alpha
3. American Federation for Clinical Research
4. American Society for Microbiology
5. Southern California Tissue Culture Association, 1962
6. Infectious Diseases Society of America, October 23, 1967
7. Western Society for Clinical Research, February 1968
8. Western Association of Physicians, February 1981
9. Los Angeles County Academy of Medicine
10. ASM, Southern California
11. International AIDS Society
Research Activities
Research Interests
1. Viral disease, particularly of CNS.
2. Evaluation of antibiotic, chemotherapeutic and immunizing agents.
3. Bacterial meningitis
4. The biology of Neisseria meningitidis
5. AIDS: PI USC ACTU, funded by NIH since its inception in July 1986. PI since 1985, USC, California Collaborative Treatment Group, funded by the State of CA.
Journal Articles
1. Leedom JM, Barkulis SS: Studies on virulence of Group A beta hemolytic streptococci. J Bact 78:687-694, 1959.
2. Leedom JM, Kennedy RP, Lepper MH, Jackson GG, Dowling HF: Changes in nasal flora in patients and contracts when methicillin was used extensively on hospital wards. Antimicrob Agents and Chemother-1961, 683-660, 1963.
3. Leedom JM, Pritchard JC, Keer LM: Probable acute histoplasma pericarditis with effusion: report of a case with recurrence. Arch Int Med 112:652-660, 1963.
4. Wehrle PF, Leedom JM, Portnoy B, Pierce NF, Cowper HH: Safety of Sabin oral poliovaccine strains, Los Angeles County, 1962-1963. JAMA 186:821-826, 1963.
5. Ivler D, Thrupp L, Leedom JM, Wehrle PF, Portnoy B: Ampicillin in the treatment of acute bacterial meningitis. Antimicrob Agents and Chemother-1963, 335-345, 1964.
6. Thrupp LD, Leedom JM, Ivler D, Wehrle PF, Brown JF Jr, Mathies AW Jr, Portnoy B: H. influenzae meningitis: a controlled study of treatment with ampicillin. Postgrad Med J (Suppl)40:119-125, December 1964.
7. Portnoy B, Leedom JM, Hanes B, Wehrle PF: Factors affecting ECHO 9 virus recovery from cerebrospinal fluid. Amer J Med Sci 248:521-527, November 1964.
8. Portnoy B, Leedom JM, Hanes B, Kunzman EE, Pierce NF, Wehrle PF: Aseptic meningitis associated with ECHO virus Type 9 infection with special reference to variability by sex and incidence of paralytic sequelae. Calif Med 102:261-267, April 1965.
9. Leedom JM, Kennedy RP: Apercu de quelques experience L@hebergement des staphylocoques au niveau de nez. Medecine et Hygiene 23:384-386, April 14, 1965.
10. Leedom JM, Graham AC, Byer MA: Epidemic poliomyelitis in Barbados, West Indies-1963. Public Health Reports 80:423-431, May 1965.
11. Leedom JM, Graham AC, Byer MA: Epidemia de poliomielitis en Barbada, Indias Occidentales. Bol Ofic Sanit Panamer 59:22-23, July 1965.
12. Ivler D, Leedom JM, Thrupp LD, Mathies AW Jr, Wehrle PF, Portnoy B: Naturally occurring sulfadiazine resistant meningococci. Antimicrob Agents and Chemother-1964, 444-450, 1965.
13. Leedom JM, Kennedy RP, Lepper MH, Jackson GC, Dowling HF: Observations of the staphylococcal nasal carrier state. Ann NY Acad Sci 128:381-403, July 23, 1965.
14. Leedom JM, Ivler D, Mathies AW, Thrupp LD, Wehrle PF: The importance of sulfadiazine resistance in meningococcal disease in civilians. N Engl J Med 273:1395-1401, December 23, 1965.
15. Mathies AW Jr, Leedom JM, Thrupp LD, Ivler D, Portnoy B, Wehrle PF: Experience with ampicillin in bacterial meningitis. Antimicrob Agents and Chemother-1965, 610-617, 1966.
16. Leedom JM, Portnoy B, Mathies, AW, Eckert HL: A preliminary survey of respiratory virus infections in patients with haemophilus influenzae meningitis. Antimicrob Agents and Chemother-1965, 37-43, 1966.
17. Ivler D, Leedom JM, Mathies AW Jr, Fremont JC, Thrupp LD, Portnoy B, Wehrle PF: Correlates of sulfadiazine resistance in meningococci isolated from civilians, Antimicrob Agents and Chemother-1965, 358-365, 1966.
18. Thrupp LD, Leedom JM, Ivler D, Wehrle PF, Portnoy B, Mathies AW Jr: Ampicillin levels in the cerebrospinal fluid during treatment of bacterial meningitis. Antimicrob Agents and Chemother-1965, 206-213, 1966.
19. Leedom JM, Ivler D, Mathies AW, Thrupp LD, Fremont J, Wehrle PF, Portnoy B: The problem of sulfadiazine resistant meningococci. Antimicrob Agents and Chemother-1966, 281-292, 1967.
20. Wehrle PF, Mathies AW Jr, Leedom JM: Management of bacterial meningitis. Clin Neurosurg 14:72, 1967.
21. Wehrle PF, Mathies AW Jr, Leedom JM, Ivler D: Bacterial meningitis. Ann New York Acad Sci 145:488-498, Art 2, September 27, 1967.
22. Portnoy B, Salvatore M, Hanes B, Hammer DI, Leedom JM, Jambazian A, Eckert HL: The sensitivity of the adenovirus complement fixation test for the serodiagnosis of lower respiratory disease in infants and children. Am J Epidem 86:362-371, September 1967.
23. Wilkins J, Salvatore MA, Portnoy B, Leedom JM: Viremia in a recipient of HPV-77 rubella virus vaccine. Calif Med 110:224-227, March 1969.
24. Leedom JM, Wehrle PF, Mathies AW Jr, Ivler D, Warren WS: Comments about the role of gentamicin in the treatment of meningitis in neonates. J Infect Dis 119:476-480, No. 4&5, April-May 1969.
25. Mathies AW Jr, Leedom JM, Ivler D, Wehrle PF, Portnoy B: Antibiotic antagonism in bacterial meningitis. Antimicrob Agents and Chemother-1967, 218-224, 1968.
26. Wilkins J, Leedom JM, Portnoy B, Salvatore MA: Reinfection with rubella virus despite live vaccine induced immunity (trials of HPV-77 and HPV-80 live rubella virus vaccines and subsequent artificial and natural challenge studies). Amer J Dis Child 118-275, 1969.
27. Wehrle PF, Mathies AW Jr, Leedom JM: Management of acute bacterial meningitis. Ped 44:991, 1969.
28. Brown JD, Mathies, AW Jr, Ivler D, Warren SS, Leedom JM: Variable results of cephalothin therapy for meningococcal meningitis. Antimicrob Agents and Chemother-1969, 432-440, 1970.
29. Ivler D, Leedom JM, Mathies AW Jr: In vitro susceptibility of neisseria meningitidis to rifampin. Antimicrob Agents and Chemother-1969, 473-478, 1970.
30. Leedom JM, Wilkins J, Portnoy B, Salvatore MA: Important assumptions extrapolations and established facts underlying the use of live rubella virus vaccines. Amer J Epidemiol 93:151-157, 1970.
31. Wilkins, J Leedom JM, Salvatore MA, Portnoy B: Transmission of rubella vaccine virus from vaccines to contacts. Calif Med 115:16-22, November 1971.
32. Lavetter A, Leedom JM, Mathies AW, Ivler D, Wehrle PF: Meningitis due to listeria monocytogenes. A review of 25 cases. N Engl J Med 285:598-603, September 1971.
33. Mathies AW, Lavetter A, Leedom JM, Ivler D, Wehrle PF: Gentamicin in the treatment of meningitis. Adapted from a discussion presented at the Conference on Gentamicin, Los Angeles, California, January 26, 1971, at the University of California at Los Angeles. J Infect Dis 124 (Suppl): S249-S253, December 1971.
34. Wilkins J, Leedom JM, Portnoy B: Epidemiological implications of rubella vaccine failures. Amer J Dis Child 123:31-33, January 1972.
35. Wilkins J, Leedom JM, Salvatore MA, Portnoy B. Responses of previously reinfected rubella vaccines to challenge with Brown strain rubella virus. Calif Med 12-17, December 1972.
36. Wilkins J, Leedom JM, Salvatore MA, Portnoy B. Clinical rubella with arthritis resulting from reinfection. Ann Int Med 77:930-932, 1972.
37. Overturf GD, Wilkins J, Leedom JM, Ivler D, Mathies AW: Susceptibility of hemophilus influenzae, Type B to ampicillin at LAC+USC Medical Center: a reappraisal after 10 years. J Pediat 87:297-300, 1975.
38. Berman NS, Siegal SE, Nachum R, Lipsey A, Leedom JM: Cerebrospinal fluid endotoxin concentrations in gram negative bacterial meningitis. J Pediat 88:553-556, 1976.
39. Overturf GD, Steinberg EA, Underman AE, Wilkins J, Leedom JM, Mathies AW Jr, Wehrle PF: Comparative study of carbenicillin and ampicillin in the treatment of purulent meningitis. Antimicrob Agents and Chemother 11:420-426, 1977.
40. Overturf GD, Horowitz M, Wilkins J, Leedom JM, Steinberg EA: Bacterial studies of penicillin-gentamicin combinations against Group B streptococci. J Infect Dis 30(6):513-518, June 1977.
41. Steinberg EA, Overturf GD, Wilkins J, Baraff L, Streng JG, Leedom JM: Failure of cefamandole in the treatment of Haemophilus influenzae meningitis. J Infect Dis 137:(Suppl)S18-0186, May l978.
42. Wilkins JW, Leedom JM, Overturf GD, Baraff L: Differential inactivation of cephapirin versus cephalothin by penicillin-resistant strains of S. aureus: a preliminary report. J Infect Dis 137:494-497, April 1978.
43. Orenstein WA, Overturf GD, Leedom JM, et al: The frequency of Legionella infection determined serologically in children hospitalized with pneumonia. J Pediat 99(3):403-406, September 1981.
44. Heseltine PNR, Appleman MD, Leedom JM: Epidemiology and susceptibility of resistant Bacteroides fragilis group organisms to new beta-lactam antibiotics. Rev Inf Dis:6(Suppl I) March-April 1984.
45. Corigliano BE, Appleman MD, Heseltine PNR, Leedom JM: Comparative in vitro activities of norfloxacin (MK-0366) and six commonly used antimicrobial agents against 199 urinary isolates showing various degrees of antibiotic resistance. Diag Microbiol Infect Dis 2:101-106, 1984.
46. Hartman BD, Leedom J, Lewis WP, Weintraub P: Postsurgical toxic shock syndrome: report of a case in which full syndrome manifestations were aborted by early recognition and therapy. J AOA 84(4):356/93-359/96, December 1984.
47. Heseltine PNR, Ripper M, Wohlford P, Leedom JM: Rubella among hospital personnel: fetal wastage and the role of a mandatory immunization program. J Infect Control 6:371-4, 1985.
48. Heseltine PNR, Berne TV, Appleman MD, Yellin AE, Chenella FC, Leedom JM: Imipenem (thienamycin) therapy of perforated and gangrenous appendicitis. Surg Gynecol Obstet 162:43-48, 1985.
49. Barnes P, DeLeonardis E, Feinstein D, Chandrasoma P, Leedom J: Fever and pancytopenia in an alcoholic patient. West J Med 144(1)58-62, 1986.
50. Barnes P, Leedom JM, Radin DR, Chandrasoma P: An unusual case of tuberculous peritonitis. The West J Med 144:467, 1986.
51. Gill MA, Chenella FC, Heseltine PNR, Yellin AE, Berne TV, Appleman MD, Feldman MJ, Leedom JM: Economic considerations in perforated and gangrenous appendicitis: comparison of imipenem-cilastin versus clindamycin/gentamicin. Curr Ther Res 40(2):393-402, August 1986.
52. Richman DD, Fischl MA, Grieco MH, Gottlieb MS, Volberding P, Laskin LS, Leedom JM, et al: The toxicity of 3'-azido-3'deoxythymidine (azidothymidine) in the treatment of patients with AIDS and AIDS-related complex: a double-blind, placebo-controlled trials. N Engl J Med 317:185-191, July 22, 1987.
53. Barnes P, Leedom JM. Infective endocarditis due to Clostridium sordellii. Amer J Med 83:605, 1987.
54. Fischl MD, Richman DD, Grieco MH, Gottlieb MS, Volberding PA, Laskin OL, Leedom JM, et al: The efficacy of 3'-azido-3'deoxythymidine (azidothymidine) in the treatment of patients with AIDS and AIDS-related complex: a double-blind placebo-controlled trial. N Engl J Med 317:192-197, July 22, 1987.
55. Laskin O, Cederberg D, Mils J, Leedom JM, as a member of the Ganciclovir Study Group: Ganciclovir for treatment and suppression of serious infections caused by cytomegalovirus. Amer J Med 83:201-207, 1987.
56. Heseltine PNR, Causey DM, Appleman MD, Corrados ML, Leedom JM: Norfloxacin in the eradication of enteric infections in AIDS patients. Eur J Cancer Clin Oncol 24(Suppl 1), 1988.
57. Antoniskis D, Sattler F, Leedom JM: Importance of assessing risk behavior for AIDS. Postgrad Med 83(5), April 1988.
58. Riley K, Antoniskis D, Maris R, Leedom J: Rattlesnake capsule-associated Salmonella arizona infections. Arch Intern Med 148, May 1988.
59. Barnes P, Verdegem T, Vachon L, Leedom JM, Overturf G: The chest x-ray in pulmonary tuberculosis: new data on an old test. Chest 94, August 1988.
60. Barnes P, Leedom JM, Chan L, Wong S, Shah J, Vachon L, Overturf G, Modin R: Predictors of short-term prognosis in patients with pulmonary tuberculosis. J Infect Dis 158(5), August 1988.
61. Richman DD, Andrews J, Leedom J, et al, as member of the AZT Collaborative Working Group: Results of continued monitoring of participants in the placebo-controlled trial of zidovudine for serious human immunodeficiency virus infection. Amer J Med 85(Suppl 2A)208-l3, l988.
62. Shibata D, Appleman MD, Causey DM, Leedom JM, et al: Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. J Infect Dis l58:ll85-92, l989.
63. Fischl MA, Richman DD, Grieco MH, Leedom J, et al, as a member of the AZT Collaborative Working Group: Experience with prolonged zidovudine therapy in patients with AIDS and advanced AIDS-related complex. JAMA 262:2405-24l0, November 3, l989.
64. Schmitt FA, Bigley JW, McKinnis R, et al, and Leedom JM, as a member of the AZT Collaborative Working Group: Neuropsychological Outcome of Zidovudine (AZT) Treatment of Patients with AIDS and AIDS-Related Complex. N Engl J Med 3l9:l573-78, l988.
65. Arevalo C, Barnes PF, Duda M, Leedom JM: Cerebrospinal fluid cell counts and chemistries in bacterial meningitis. South Med J 82(9)ll22-ll27, September l989.
66. Ito MK, Gill MA, Yellin AE, Berne TV, Heseltine P, Appleman MA, Leedom J: The cost effectiveness of sulbactam-ampicillin versus moxalactam in the management of acute cholecystitis. Curr Ther Res 46(4):October l989.
67. Sattler FR, Allegra CJ, Verdegem TD, Akil B, Tuazon CU, Hughlett C, Ogata-Arakaki D, Feinberg J, Shelhamer J, Lane HC, Davis R, Boylen C, Leedom J, Masur H: Trimetrexate-leukovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia. J Infect Dis l6l:9l-96, l990.
68. Volberding P, et al, and Leedom J, as a member of the ACTG. Zidovudine in human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases. N Engl J Med 322(l4):94l-9, April 5, l990.
69. Kramer F, Modilevsky T, Wallany A, Leedom J, Barnes P: Delayed diagnosis of tuberculosis in patients with human immunodeficiency virus infection. Amer J Med 89:45l-456, October l990.
70. Larsen RA, et al, and Leedom JM, as a member of the California Collaborative Treatment Group. Persistent Cryptococcus neoformans prostatic infection after successful treatment of meningitis. Ann Intern Med lll:l25-l28, l989.
71. Roberts RB, Dickinson GM, Heseltine PNR, Leedom JM, et al: A multicenter clinical trial of oral ribavirin in HIV-infected patients with lymphadenopathy. J AIDS Syndromes 3:884-892, October l990.
72. Fischl MD, and Leedom JM, as a member of the AZT collaborative Working Group. A randomized controlled trial of a reduced daily dose of zidovudine in patients with the AIDS syndrome. N Engl J Med 323(l5):l009-l0l4, October l990.
73. Collier Ann, Leedom JM, et al: A pilot study of low-dose zidovudine in human immunodeficiency virus infection. N Engl J Med 323:l0l5-l02l, October l990.
74. Chiu J, Nussbaum J, Bozzette S, Tilles JG, Young L, Leedom JM, Heseltine PN, McCutchan AJ, and the California Collaborative Treatment Group: Treatment of disseminated Mycobacterium avium complex infection in AIDS with amikacin, ethambutol, rifampin, and ciprofloxacin. Ann Intern Med ll3:358-6l, l990.
75. Antoniskis D, Larsen R, Akil B, Rarick M, Leedom JM: Seronegative disseminated coccidioidomycosis in patients with HIV infection. AIDS 4(7):69l-3, July l990.
76. Bozzette SA, Sattler F, Chiu J, Wu AL, Gluckstein D, Kemper C, Akil B, Meng TC, Abrahamson I, Coffman J, Hughlett C, Loya R, Niosi J, Bartok A, Cassins B, Boylen T, Richman DD, Nielsen D, Tillis J , Leedom J, McCutchan JA, and the California Collaborative Treatment Group. A controlled trial of adjunctive corticosteroids for Pneumocystis carinii pneumonia in the Acquired Immunodeficiency Syndrome. N Engl J Med 323:l45l-l457, November l990.
77. Bozzette SA, Larsen RA, Chiu J, Leal MA, Leedom, JM, Richman DD, McCutchan JA: Fluconazole treatment of persistent Cryptococcus neoformans prostatic infection in AIDS. Ann Intern Med 115:285-286, August l5, l992.
78. Bozzette SA, Larsen RA, Chiu J, Leal MA, Jacobsen J, Rothman P, Robinson P, Gilbert G, McCutchan JA, Tilles J, Leedom JM, Richman DD: A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. N Engl J Med 324:580-4, 1991.
79. Sattler FR, Ko R, Antoniskis D, Shields M, Cohen J, Nicoloff J, Leedom J, and Koda R: Acetaminophen does not impair clearance of zidovudine. Ann Intern Med ll4(11):937-940, June l991.
80. Dannemann B, McCutchan JA, Israelski D, Antoniskis D, Leport C, Luft B, Nussbaum J, Clumeck N, Moriat P, Chiu J, Vilde J-L, Orellana M, Feigal D, Bartok A, Heseltine P, Leedom J, Remington J, and CCTG. Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. Ann of Intern Med ll6(l):33-43, January l, l992.
81. Kemper CA, Meng T-C, Nussbaum J, Chiu J, Feigal DF, Bartok MPH, Leedom J, et al: Treatment of Mycobacterium avium Complex Bacteremia in AIDS with a Four-Drug Oral Regimen: Rifampin, Ethambutol, Clofazimine, and Ciprofloxacin. Ann of Intern Med ll6(6):466-472, March l992.
82. Leedom JM: Pneumonia. Patient profiles, choice of empiric therapy, and the place of third-generation cephalosporins. Diag Microbiol and Infect Dis 15(1):57-65, January 1992.
83. Holtom PD, Larsen RA, Leal ME, Leedom JM: Prevalence of neurosyphilis in human immunodeficiency virus-infected patients with latent syphilis. Amer J Med 93(1);9-12, July 1992.
84. Bozzette SA, et al, and Leedom JM, as a member of the CCTG. Length of stay and survival after intensive care for severe Pneumocystis carinii pneumonia. A prospective study. Chest 101(5):1404-6, May 1992.
85. Skowron G, Bozzette SA, Lim L, Leedom JM, et al. Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex. Ann Int Med 118(5):321-330, March 1993.
86. Rosendorf LL, Dafni U, Amato DA, Leedom JM, et al. Performance evaluation in multicenter clinical trials: development of a model by the AIDS Clinic Trial Group. Contr Clin Trials 14:523-537, 1993.
87. Luft BJ, Hafner R, Korzun AH, et al, and Leedom JM, as a member of the ACTG 077 Study Team. Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. N Engl J Med 1993;4):995-1000.
88. Kramer F, Sasse SA, Simms JC, Leedom JM. Primary cutaneous tuberculosis after a needlestick injury from a patient with AIDS and undiagnosed tuberculosis. Ann Int Med 1993;119(7):594-5.
89. Underman A, Leedom JM. Fish and shellfish poisoning. Curr Clin Top
Infec Dis 1993;13:203-225.
90. Hughes W, et al, and Leedom JM, as a member of the ACTG Study Group. Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii in patients with AIDS. N Engl J May 1993;328(21):1521-7.
91. Kemper CA, Havlir D, Haghighat D, Dube M, Leedom J, et al. The individual microbiologic effect of three antimycobacterial agents, clofazimine, ethambutol, and rifampin, on Mycobacterium avium complex bacteremia in patients with AIDS. J Infect Dis July 1994;170:157-64.
92. Sattler FR, Frame P, Davis R, Leedom J, et al. Trimetrexate with leucovorin versus TMP-SMZ for moderate to severe episodes of Pneumocystis carinii pneumonia in patients with AIDS: a prospective, controlled multicenter investigation of the ACTG Protocol 029-031. J Infect Dis July 1994;170:165-72.
93. Larsen RA, Bozzette SA, Jones BE, Haghighat D, Leal MA, Forthal D, Bauer M, Tilles JG, McCutchan JA, Leedom JM. Fluconazole combined with flucytosine for treatment of cryptococcal meningitis in patients with AIDS. CID October 1994;19(4):741-5.
94. Bozzette SA, Forthal D, Sattler FR, Kemper C, Richman DD, Tilles JG, Leedom JM. The tolerance for zidovudine plus thrice weekly or daily trimethoprim-sulfamethoxazole with and without leucovorin for primary prophylaxis in advanced HIV disease. Amer J Med February 1995;98:177-182.
95. Reichman RC, Morse GD, Demeter LM, and Leedom JM, et al, and McCutchan JA. Phase I study of atevirdine, a non-nucleoside reverse transcriptase inhibitor, in combination with zidovudine for human immunodeficiency virus type I infection. J Infect Dis February 1995;171:297-304.
96. Havlir DV, Dube MP, Sattler FR, Forthal DN, et al, and Leedom JM, as a member of the California Collaborative Treatment Troup. Prophylaxis against disseminated Mycobacterium avium complex with weekly azithromycin, daily rifabutin or both. N Engl J Med August 1996;335(6):392-8.
97. Dube MP, Johnson DS, Currier JS, and Leedom JM. Protease inhibitor-associated hyperglycemia. Lancet 1997;350:713-4.
98. Dube MP, Sattler FR, Torriani FJ, See D, Havlir DV, Kemper CA, Dezfuli MG, Bozzette SA, Bartok AE, Leedom JM, Tilles JG, McCutchan JA. A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group. JID Nov. 1997;176(5):1225-32.
99. Demeter LM, Meehan PM, Morse G, Fischl MA, Para M, Powderly W, Leedom JM, Holden-Wiltse J, Greisberger C, Wood K, Timpone Jr, J, Wathen LK, Nevin T, Resnick L, Batts DH, Reichman RC. Phase I study of atevirdine mesylate (U-87201E) monotherapy in HIV-1-infected patients. J AIDS & Hum Retrov 1998;19;135-144.
100. Robinson PA, Bauer M, Leal MA, Evans SG, Holtom PD, Diamond DM, Leedom JM, Larsen RA. Early mycological treatment failure in AIDS-associated cryptococcal meningitis. CID 1999;28-82-92.
101. Dube MP, Torriani FJ, See D, Havlir DV, Kemper CA, Leedom JM, Tilles JG, McCutchan JA, Sattler FR. Successful short-term suppression of clarithromycin-resistant Mycobacterium avium complex bacteremia in AIDS. Clin Infect Dis 1999;28:136-8.
102. Leedom JM, Underman AE. Epidemiology of central nervous system infections. Neuroimag Clin NA 10 May 2000(2);297-308.
103. Morse GD, Reichman RC, Fischl MA, Para M, Leedom J, Powderly W, Demeter LM, Resnick L, Bassiakos Y, Timpone J, Cox S, Batts D. Concentration-targeted Phase I trials of atevirdine mesylate in patients with HIV infection: dosage requirements and pharmacokinetic studies. The ACTG
187 and 199 study teams. Antiviral Res, Jan 2000, 45(1):47-58.
104. Villacres MC, Lacey S, LaRosa C, Krishnan R, Auge C, Longmate J, Zaia JA, Leedom JM, Diamond DJ. Human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy maintain activated CD8 T cell subsets as a strong adaptive immune response to cytomegalovirus. JID, 2001:184(3).
105. Kemper CA, Witt MD, Keiser PH, Dube MP, Forthal DN, Leibowitz M, Smith DS, Rigby A, Hellman S, Lie YS, Leedom JM, Richman D, McCutchan JA, Haubrich R, and CCTG Group #575 Team. Sequencing of protease inhibitor therapy: insights from an analysis of HIV phenotypic resistance in patients failing protease inhibitors. AIDS 2001, 15:609-615.
106. Haubrich RH, Currier JS, Forthal DN, Beall G, Kemper CA, Johnson D, Dube
MP, Hwang J, Leedom JM, Tilles J, McCutchan JA, and the CCTG. A randomized study of the utility of human immunodeficiency virus RNA measurement for the management of antiretroviral therapy. CID Oct 2001:33.
Abstracts
1. Thrupp LD, Ivler D, Leedom JM and Portnoy B: Sensitivity of N meningitidis to sulfadiazine and trimethoprim in vitro. Bacterial Proc 66:52, 1966.
2. Leedom JM, Ivler D, Mathies AW, Jr, Portnoy B and Wehrle PF: Serogroup C N meningitidis and unfavorable prognosis in meningococcal disease. Clin Res 16:127, January 1968.
3. Ivler D, Hammond VB, Leedom JM and Mathies AW, Jr: Antibody response to Meningococcal and Hemophilus influenzae meningitis. Clin Res 19:213(1), 1971.
4. Leedom JM, Ivler D, Mathies AW Jr and Wehrle PF: Positive correlation of sulfadiazine resistance with disease production among both Group B and Group C meningococci during a seven-year period. Clin Res 19:184(1), 1971.
5. Berman N, Siegal S, Lipsey A, Leedom JM and Nacum R: Quantification of cerebrospinal fluid (CSF) endotoxin in gram-negative bacterial meningitis. 14th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 12, 1974. Abstract #271, in published program. Presented by Dr. Berman.
6. Overturf G, Mathies A, Ivler D, Leedom JM, Wilkins J, Wehrle P: Susceptibility of hemophilus influenzae, Type B, to ampicillin after 12 years of use. Clin Res 23:154A, February 1975. Infectious Disease Subspecialty Meeting, AFCR, WSPR, Carmel, CA. Presented February 6, 1975, by Dr. Overturf.
7. Maronde RF, Brodie DC and Leedom JM: Data collection and analysis of drug usage in an outpatient pharmacy. In Program and Abstracts, International Symposium on Clinical Pharmacy and Pharmacology. Symposium sponsored by the New England Medical Center, Boston, MA. Presented September 19, 1975, by Dr. Maronde.
8. Underman AE, Leedom JM and Maronde RF: Use of anti-infectives in an outpatient setting in a large public hospital. Presented in a session entitled, Antibiotics Physicians are Actually Prescribing, at the 125th Annual Convention of the American Medical Association, Dallas, TX, June 29, 1976, Page 52 of the AOffician Program.@ Presentation by Dr. Maronde and Dr. Leedom.
9. Steinberg EA, Overturf, GD, Wilkins J, Baraff L, Streng JM Leedom JM: Failure of cefamandole in treatment of meningitis due to Haemophilus influenzae, Type B, Symposium on Cefamandole, Boca Raton, FL, March 17-19, 1977. Presented by Dr. Overturf.
10. Wilkins J, Leedom JM, Overturf GD and Baraff LJ: Differential inactivation of cephapirin versus cephalothin by penicillin-resistant strains of Staphylococcus aureus. 16th Interscience Conference on Antimicrobial Agents and Chemotherapy, sponsored by the American Society for Microbiology, Abstract #208. Presented by Dr. Wilkins at Chicago, IL, October 28, 1976.
11. Overturf GD, Horowitz M, Wilkins J, Leedom JM and Steinberg AE: Bacterial studies of penicillin-gentamicin combinations against Group B streptococci. Streptococcus Club, Chicago, IL, October 26, 1976.
12. Gilman A, Forrest K, Schuttenhelm K, Rodman J, Schumitzky A, Underman AE, Leedom JM, Wilkins J, Overturf G, Crone J and Jelliffe R. Clinical studies with a computer program of adoptive control of tobramycin dosage. American Society of Hospital Pharmacists, San Antonio, TX, December 6, 1978.
13. Heseltine PNR, Appleman MD, Yee J, Wilkins J and Leedom JM: Epidemiology and antibiotic susceptibility on 300 gentamicin resistant isolates at a large municipal hospital. 19th International Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, October 1-4, 1979.
14. Heseltine PNR, Leedom JM and Appleman MD: Synergy of CP45-8999 with ampicillin against methicillin resistant Staphylococcus aureus. 80th Annual Meeting American Society for Microbiology, Miami Beach, FL, May 1980.
15. Orenstein WA, Overturf GD and Leedom JM. The relative frequency of Legionnaires Disease in children hospitalized with pneumonia. 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Louisiana, September 22-24, 1980.
16. Corigliano BE, Appleman M and Leedom JM. In vitro efficacy of MK-0366 (AM 715) against antibiotic susceptible and resistant urinary tract
pathogens. 21st International Conference on Antimicrobial Agents and
and Chemotherapy, Chicago, IL, November 4-6, 1981.
17. Corigliano BE, Appleman M and Leedom JM. In vitro efficacy of MK-0366 (AM 715) against antibiotic susceptible and resistant urinary tract isolates. American Society for Microbiology, 82nd Annual Meeting, Atlanta, Georgia, A45, P8, March 7-12, 1982.
18. Corigliano BE, Overturf GD and Leedom JM. Activity of cephalosporins and related compounds against Listeria monocytogenes. Clin Res 30:97A, 1982.
19. Heseltine PNR, Appleman MD and Leedom JM. In vitro activity of new beta-lactam against resistant Bacteroides fragilis group organisms. International Symposium on Anaerobic Bacteria, Santa Monica, CA, October 11-13, 1982.
20. Yellin AE, Berne TV, Heseltine PNR, Appleman MD, and Leedom JM. Sulbactam-ampicillin versus moxalactam as an adjunct to surgery in acute cholecystitis. 14th International Congress of Chemotherapy, Kyoto, Japan, 1985.
21. Heseltine PNR, Yellin AE, Appleman MD, Berne TV, and Leedom JM. Imipenam (Thienamycin) therapy of perforated and gangrenous appendicitis. 14th International Congress of Chemotherapy, Kyoto, Japan, 1985.
22. Heseltine PNR, Meyer P, Appleman MD, Leedom JM, Ripper M, and Causey D. Economics and healthcare requirements of patients with LAV/HTLV-III related diseases at a large municipal hospital, 2nd International Conference on AIDS, Paris, 1986.
23. Causey D, Eppolito LJ, Heseltine PNR and Leedom JM. Blastocystis hominis diarrhea in AIDS/ARC patients. 2nd International Conference on AIDS, Paris, 1986.
24. Causey D, Leedom JM and Heseltine PNR. Cerebrospinal fluid penetration of 9-(1,3-Dihydroxy-2-Propoxymethyl) guanine (DPHG, BW B 758 U) in AIDS patients with cytomegalovirus infections. 2nd International Conference on AIDS, Paris, 1986.
25. Roberts RB, Heseltine PNR, Mansell PWA, Dickinson GM, Leedom JM, and Johnson, KM. Ribavirin delays progression of the lymphadenopathy syndrome to the acquired immune deficiency syndrome. Western Regional Meets, American Federation for Clinical Research, Carmel, CA, February 1987.
26. Yellin A, Berne T, Heseltine P, Appleman M, Gill M, and Leedom JM. A controlled trial of sulbactam-ampicillin vs. Moxalactam as an adjunct to surgery in the therapy of acute cholecystitis. 15th International Congress of Chemotherapy, Istanbul, Turkey, July 1987.
27. Causey DM, Leedom JM and Heseltine P. Major opportunistic infections in AIDS patients after more than eight weeks of Azidothymidine (AZT) therapy. 3rd International Conference on AIDS, Washington, 1987.
28. Causey DM, Freeman WB, Henderly DE, Wan WL, Rao NA, Leedom JM, et al. Retinal Detachment in treatee cytomegalovirus retinitis. 3rd International Conference on AIDS, Washington, 1987.
29. Causey DM, Heseltine P, Appleman M and Leedom JM. Norfloxacin in the eradication of Salmonella infections in AIDS patients. 3rd International Conference on AIDS, Washington, 1987.
30. Barnes PF, Leedom JM, Chan LS, Wong SF, Vachon LA and Overturf GD. Predicting prognosis in pulmonary tuberculosis. 26th ICAAC, New Orleans, Louisiana, September 29, 1986.
31. Barnes PF, Leedom JM, Chan LS, Wong SF and Overturf GD. Drug resistance in pulmonary tuberculosis. 26th ICAAC, New Orleans, LO, September 29, 1986.
32. Howard J, Sattler F, Mahon R, Sperling J and Leedom JM. Clinical and immunological features of 100 HIV antibody positive individuals from an alternate test site. 3rd International Conference of AIDS, Washington, DC, June 1987.
33. Mansell P, Heseltine P, Roberts R, Dickinson G, Leedom J, et al. Ribavirin delays progression of the lymphadenopathy syndrome to the acquired immunodeficiency syndrome (AIDS). 3rd International Conference on AIDS, Washington, DC, June 1987.
34. Heseltine P, Leedom JM, Hedderman M, Ripper M and Sattler F. Comprehensive outpatient-based healthcare reduces inpatient stay for persons with AIDS or ARC. 3rd International Conference on AIDS, Washington, DC, June 1987.
35. Causey D, Eppolito LJ, Heseltine PNR and Leedom JM. Blastocystis hominis diarrhea in AIDS/ARC patients. 3rd International Conference on AIDS, Washington, DC, June 1987.
36. Yellin A, Berne T, Heseltine P, Appleman M, Gill M, Leedom JM. A controlled trial of sulbactam-ampicillin vs. Moxalactam as an adjunct to surgery in the therapy of acute cholecystitis. 15th International Congress of Chemotherapy, Instanbul, Turkey, July 1987.
37. Causey DM, Leedom JM and Heseltine PNR. Major opportunistic infections in AIDS patients after more than eight weeks of Azidothymidine therapy. 3rd International Conference on AIDS, Washington, 1987.
38. Heseltine P, Bridge T, Ito M, Ruff M, Hill M, Pert C and Leedom J. Phase I study of peptide T in AIDS: pharmacology and immune response. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988.
39. Bozzette S, Larsen R, Chiu J, Tilles J, Leedom J, McCutchan J and Richman D. Low incidence of early relapse in cryptococcal meningitis after exclusion of persistent systemic and genitourinary infection. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988.
40. Sattler F, Allegra C, Tuazon C, Akil B, Verdegem T, Arakaki D, Hughlett C, Boylen T, Lane C, Feinberg J, Chabner B, Leedom J and Masur H. Trimetrexate and Leucovorin for Pneumocystis carinii pneumonia. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988.
41. Causey D, Eppolito L and Leedom JM. Blastocystis hominis diarrhea in HIV-infected patients. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988.
42. Causey D, Leedom JM and Melancon H. Major opportunistic infections in AIDS patients after 8-100 weeks of zidovudine therapy. IV International Conference on AIDS, Stockholm, Sweden, June 12-16, 1988.
43. Dannemann BR, Israelski DM, McCutchan JA, Leedom JM, et al. Treatment of toxoplasmic encephalitis in patients with AIDS: preliminary report of the California Collaborative Treatment Group Randomized Trial of Pyrimethamine plus Sulfonamides vs Pyrimethamine plus Clindamycin. 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, CA, October 23-26, 1988.
44. Akil B, Allegra C, Leedom JM, et al. Dose escalation toxicity trial of trimetraxate-leucovorin in AIDS patients with Pneumocystis carinii Pneumonia. 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, CA, October 23-26, 1988.
45. Heseltine PNR, Bridge T, Ito M, Leedom JM, et al. Phase I study of zidovudine and interferon Alfa-2B (Intron) in human immunodeficiency virus disease. 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, CA, October 23-26, 1988.
46. Goodwin F, Heseltine P, Bridge T, Martin J and Leedom JM. Peptide T Phase I Study: immuno-virologic results. V International Conference on AIDS, Montreal, Canada, June 1989.
47. Nussbaum J, Antoniskis D, Causey D and Leedom, JM. Toxicity of combined AZT/ganciclovir therapy in AIDS patients. V International Conference on AIDS, Montreal, Canada, June 1989.
48. Koda R, Ko Richard J, Antoniskis D, Shields M, Melancon H, Cohen J, Leedom JM and Sattler F. Effect of acetaminophen on the pharmacokinetics of zidovudine. V International Conference on AIDS, Montreal, Canada, June 1989.
49. Antoniskis D, Nussbaum J, Dannemann B, McCutchan J and Leedom J. Long-term survival of AIDS patients successfully treated for toxoplasmic encephalitis. V International Conference on AIDS, Montreal, Canada, June 1989.
50. Causey D, Leedom J and Melancon H. Major oppotunistic infections in AIDS patients after 8-150 weeks of zidovudine therapy. V International Conference on AIDS, Montreal, Canada, June 1989.
5l. Antoniskis D, Rarick M, Akil B, Larsen R and Leedom JM. Seronegative disseminated coccidioidomycosis in patients with HIV infections. V International Conference on AIDS, Montreal, Canada, June l989.
52. Causey D, Leedom JM and Olsen C. Rhodotorula rubra septicemia in an AIDS patient with an indwelling Hickman catheter. V International Conference on AIDS, Montreal, Canada, June l989.
53. Collier A, Coombs, Bozzette S, Spector S, Pettinelli C, Richman D, Causey D, Leedom JM, Davies G, Gianola F, and Corey L. Virologic and clinical response to combination zidovudine (AZT) and acyclovir (ACV) in AIDS-related complex. 29th Annual Interscience Committee on Antimicrobial Agents and Chemotherapy, Houston, Texas, l989.
54. Heseltine PNR, Martin J and Leedom JM. Peptide T Phase I study: immunologic/virologic results. VI International Conference on AIDS, San Francisco, CA, June l990.
55. Dannemann BR, McCutchan JA, Israelski DM, Antoniskis D, Leporte C, Luft BJ, Chiu J, Wilde JL, Nussbaum JN, Orellana M, Heseltine PNR, Leedom JM, et al. Treatment of toxoplasmic encephalitis (TE) in patients with AIDS: a randomized trial comparing pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfonamide (PS). 30th Interscience Conference on Antimicrobial Agents and Chemotherapy. Atlanta, Georgia, October 2l-24, l990.
56. Heseltine P, Eaton E, Buchshaum M, Parker E, McGrail M, Leedom J, and Bridge P. Effect of Peptide T on AIDS dementia complex (ADC): correlation of PET scans and cognitive domains. Abstracts MB2006.l.l83. VII International Conference on AIDS. Florence, Italy, June l7, l99l.
57. Leedom J: Patients profiles, choice of empiric therapy and the place of third generation cephalosporins. Abstract #904. International Congress of Chemotherapy, Berlin, Germany, June 26, l99l.
58. Jones B, Larsen R, Bozzette S, Haghighat D, Leedom J,
McCutchan J. A phase III trial of fluconazole plus flucytosine for cryptococcal meningitis. 7th International Conference on AIDS, Florence, Italy, June l6-2l, l99l.
59. Kemper C, Holtom P, Feigal D, Rickman L, Leedom J, McCutchan A, Deresinski S, and the CCTG. RPR, CD4 and CSF findings in HIV infection and syphilis. 3lst ICAAC, Chicago, IL, September l99l.
60. Kemper C, Havlir D, Haghighat D, Dube M, Yangco B, Leedom J, Tillis J, McCutchan JA, Deresinski SC. The California Collaborative Treatment Group. Effect of Ethambutol, Rifampin, Clofazimine in combinations of two, on M. avium bacteremia. 32nd ICAAC, Anaheim, CA, October 1992.
61. Jones B, Appleman M, Leedom J, Heseltine PNR. Changes in frequency and severity of Group A streptococcus bacteremias. American Federation for Clinical Research, Carmel, CA, February 1992.
62. Stein D, Corey L, Volberding P, Leedom JM, et al. Preliminary safety and activity evaluation of new agents for the treatment of HIV-1 infection: recommended guidelines for trial design. 13th Annual Society Meeting for Clinical Trials, Philadelphia, PA, May 11-13, 1992.
63. Soave R, Havlir D, Lancaster D, Joseph P, Leedom J, Clough W, Geiseler PJ, Dunne J. Azithromycin therapy of AIDS-related cryptosporidial diarrhea: A multi-center, placebo-controlled, double-blind study. 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), New Orleans, LA, October 1993.
64. Morse G, Fischl M, Leedom J, et al, and the ACTG 199 Study Group, DAIDS, NIH and the Upjohn Co. Atevirdine (ATV) pharmacokinetics (PK) and dosage requirements during a concentration-targeted (CT) phase I study (ACTG 199). IXth International Conference on AIDS, Berlin, June 1993.
65. Reichman R, Demeter L, Fischl M, Para M, Powderly W, Leedom J, et al, and the ACTG 187 Team. Phase I study of atevirdine (ATV), a non-nucleoside reverse transcriptase inhibitor. First National Conference on Human Retroviruses and Related Infections. Washington, D.C., December 1993.
66. Soave R, Havlir D, Lancaster D, Josph P, Leedom J, Clough W, Geiseler PJ, Dunne J. Azithromycin therapy of AIDS-related cryptosprodial diarrhea: A multi-center, placebo-controlled, double-blind study. Presented at the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), New Orleans, LA, October 1993.
67. Sattler FR, Dube MP, Montgomery AB, Lopresti J, Leedom J, Nicoloff J. Phase I study of insulin-like growth factor-1 in HIV. In: Program and Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1994.
68. Dube MP, Johnson DL, Currier JS, Leedom JM. Hyperglycemia associated with protease inhibitors. 23rd AIDS Clinical Trials Group Meeting, Washington, D.C., 1997.
69. Milefchik E, Leal M, Haubrich R, Bozzette S, Tilles J, Leedom
J,McCutchan JA, Larsen RA. A phase II dose escalation trial of high dose fluconazole with and without flucytosine for AIDS associated cryptococcal meningitis. Selected for presentation at the 4th Conference on Retroviruses & Opportunistic Infections, Washington, D.C., January 22-26, 1997.
Chapters in Books
1. Portnoy B and Leedom JM. Current Pediatric Therapy - III. Section of Enteroviruses. Edited by Gellis and Kagan, WB Saunders Co, pp 820-823, 1967.
2. Portnoy B and Leedom JM. Current Pediatric Therapy-Four sections on Enteroviruses. Edited by Gellis and Kagan, WB Saunders Co, pp 877-881, 1970.
3. Mathies AW and Leedom JM. Varicella dn herpes zoster. In Tice=s Practice of Medicine, 4:1-7, Chapter 17, Harper and Row, Inc., Hagerstown, Maryland, 1970.
4. Leedom JM. Chapter on Poliomyelitis. In Current Diagnosis, 3rd Edition. Edited by Conn, HF, and Conn, RB, Jr. WB Saunders Co., Philadelphia, PA, pp 138-153, 1971.
5. Leedom JM. Chapter on Pneumococcal Infections. In Brenneman=s Practice of Pediatrics, Vol II, Chapter 8, pp 1-32. Edited by Kelley, VG, Harper and Rowe, Inc., Hagerstown, Maryland, 1972.
6. Leedom JM. Psittacosis. In Current Therapy 1972. Edited by Conn, HF, pp 37-40, WB Saunders Co., Philadelphia, PA.
7. Portnoy B and Leedom JM. Enterovirus Infections. In Current Pediatric Therapy, Fifth Edition. Edited by Gellis S and Kagan B, WB Saunders Co., Philadelphia, pp 626-629, 1971.
8. Leedom JM. AQ@ Fever. In Tice=s Practice of Medicine. Edited by Eickhoff, TC. Vol III, Chapter 47, pp 1-19, Harper and Row Publishers Inc. Hagerstown, MD, 1974.
9. Leedom JM. AQ@ Fever. In Current Therapy, 1974. Edited by Conn, HF, WB Saunders Co., Philadelphia, pp 46-48, 1874.
10. Leedom JM. Poliomyelitis. In Current Diagnosis, 4th Edition. Edited by Conn, HF, and Conn, RB, Jr., WB Saunders Co., Philadelphia, PA, pp 138-142, 1974.
11. Brown JD and Leedom JM. Pneumonias, Bacterial. In Communicable and Infectious Diseases, Eighth Edition. Edited by Top, FH, and Wehrle, PF, CV Mosby Co., St. Louis, MO, pp 508-534, 1976.
12. Leedom JM. Epidemiology and Control of Pneumonia. In Epidemiology for the Infection Control Nurse. Edited by Barrett-Connor, E, et al. CV Mosby Co., St. Louis, pp 75-83, 1978.
13. Wehrle PF, Mathies AW and Leedom JM. Acute bacterial meningitis. In The Critically Ill Child, Second Edition, Edited by Smith, C, WB Saunders Co, Philadelphia, pp 91-104, 1977.
14. Leedom JM. Poliomyelitis. In Current Diagnosis, 5th Edition, Edited by Conn HF, and Conn RB, Jr. WB Saunders Co, Philadelphia, PA, pp 135-140, 1977.
15. Leedom JM and Loosli CG. Airborne pathogens in the indoor environment with special reference to nosocomial infections. In Aerobiology. The Ecological Systems Approach. US/IBP Synthesis Series 10. Edited by Edmonds, RL Doeden, Hutchinson and Ross, Inc. Stroudsburg, PA, pp 208-237, 1979.
16. Leedom JM. Chapter on Pneumococcal Infections. In Brenneman=s Practice of Pediatrics. Pneumococcal Infections. Edited by Vincent C. Kelley, Harper and Row Publishers, Inc, Hagerstown, MD, pp 1-21, Chapter 8, 1979.
17. Leedom JM. Q Fever. In Current Clinical Topics in Infectious Disease 1980. Edited by Remington JS and Swartz MN. McGraw-Hill Book Co, pp 304-331, 1980.
18. Leedom JM. Poliomyelitis. In Current Diagnosis, 6th Edition. Edited by Conn HF and Conn RB, R. WB Saunders Co, Philadelphia PA, pp 121-125, 1980.
19. Leedom JM and Brown JD. Pneumonias, Bacterial. In Communicable and Infectious Diseases, 9th Edition. Edited by Top FH and Wehrle PF, CV Mosby Co, St Louis, MO, pp 479-503, 1981.
20. Leedom JM. Q Fever. In Clinical Medicine. Edited by John A. Spittell, Jr. Harper & Row, Publishers, Philadelphia, pp 1-15, 1981.
21. Leedom JM. Pneumococcal Infections. In Infections in Children. Edited by Wedgewood JB, Davis SJ, Ray CG and Kelley VC, Harper & Row, Publishers, Inc, Hagerstown, MD, 1982.
22. Corigliano BE and Leedom JM. Renal Tuberculosis. In Textbook of Nephrology. Edited by Massry SG, Elsevier North-Holland, Inc, Publisher, NY, 6.73-6.78, l983.
23. Reid CL, Leedom JM and Rahimtoola SH. Management of Infective Endocarditis. In Current Therapy 1983. Edited by Conn HF and Conn RB, WB Saunders, Publisher, Philadelphia, 190-197, 1983.
24. Leedom JM. Pneumococcal Infections. In Practice of Pediatrics. Edited by Kelley VC, Harper & Row, Publishers, Philadelphia, pp 1-33, 1982.
25. Reid CL, Leedom JM and Rahimtoola SH. Management of Infective Endocarditis. In Current Therapy 1984. Edited by Conn HF and Conn RB, WB Saunders, Publisher, Philadelphia, pp 178-185, 1984.
26. Leedom J. "Antibiotic Prophylaxis." In Clinical Pharmacology and Therapeutics. Ed. Maronde, R. Springer Verlag, N.Y., 1986.
27. Leedom J. "Pneumococcal Infections." In Practice of Pediatrics. Ed. Kelley, V.C., Harper & Row, Publishers, Philadelphia. Vol 3, Chapter 51, 1987.
28. Corigliano B., and Leedom J. "Renal Tuberculosis." In Textbook of Nephrology. Second Ed. Ed. Massry, S.G. William and Wilkins, Publishers, Baltimore, Maryland, l988.
29. Holtom P, Leedom J. Q Fever. In Infectious Diseases in Medicine and Surgery. Ed. Gor Gach S, Bartlett J, Blacklow NR. WB Saunders Co., 1991.
30. Leedom JM, Holtom P. AInfectious Complications in Cranial Neurosurgery. In Brain Surgery: Complication Avoidance and Management Ed. M.L. Apuzzo, Churchill Livingston, 1993.
31. Leedom JM. Pneumonia. Patient profiles, choice of empiric therapy, and the place of third-generation cephalosporins. In Diagnostic Microbiology and Infectious Disease. Vol 15(1):57-65, 1992.
32. Underman AE, Leedom JM. Fish and Shellfish Poisoning. In Current Clinical Topics in Infectious Diseases. Vol 13:203-25, 1993.
33. Holtom PD, Leedom JM. Treatment of rickettsial infections. In: Current Therapy of Infectious Disease. Ed. D. Schlossberg, Mosby-Year Book, Inc. 1996.
34. Holtom PD, Leedom JM. Q Fever. In: Infectious Diseases, Second
Edition. Eds. S. Gorbach, J. Bartlett, N.R. Blacklow. W.B. Saunders Co., 1999.
35. Holtom PD, Leedom JM. Q Fever. In: Infectious Diseases, Third Edition. Eds. S Gorbach, J Bartlett, NR Blacklow. WB Saunders Co., in press, 2002.
Proceedings
1. Wehrle PF, Leedom JM and Mathies AW, Jr. Treatment of meningococcal meningitis. Modern Treatment 4:929-938, No. 5, September 1967.
2. Wehrle PF, Ivler D, Leedom JM, Mathies AW, Jr and Portnoy B. Variables important in survival from pneumococcal meningitis. In Proceedings of the 5th International Congress of Chemotherapy, pp 27-34. International Symposium on Antibiotics, Vienna, Austria, June 27, 1967.
3. Portnoy B, Wilkins, J, Leedom JM and Salvatore MA. Reinfection with rubella virus: natural and artificial challenge of HPV-77 and HPV-80 Rubella virus vaccines. Proceedings of the 23rd Symposium and Microbiological Standardization, Rubella Vaccines. International Association of Microbiological Societies Permanent Section of Microbiological Standardization. In Symposia Series in Immunological Standardization, Vol 11, pp 291-296 (Karger, Rasel, NY, 1969), London, November 1968.
4. Leedom JM, Ivler D, Mathies AW, Jr, Portnoy B, Wehrle, PF. Important considerations in the current therapy of bacterial meingitis. In Proceedings of the First Midwestern Conference on Current Trends in Antimicrobial Therapy held at Notre Dame University, pp 145-156. Publications sponsored by Department of Medical Education, St. Joseph’s Hospital, So. Bend, IN, March 19-20, 1969.
5. Wehrle PF Leedom JM. Management of the aseptic meningitis syndrome. Pediatric Portfolia l(4), April 12, 1971.
6. Leedom JM. Hospital acquired gram-negative infections: the problem of emergent bacterial resistance. In Proceedings of 9th Annual Course on Criticl Care Medicine and Shock, Section VII, Infectious Diseases, Los Angeles, CA, pp 32-34. Edited by Weil, MH. Published by USC Postgraduate Division, February 24-26, 1971.
7. Leedom JM. Overview of the problem of nosocomial infection. In Proceedings of a Conference entitled, Protecting the Patient-Environmental Controls in Hospitals and Nursing Homes, held at the University of Washington, Seattle, WA, University of Washington Press, August 11-12, 1971.
8. Maronde RF, Brodie DC and Leedom JM. Data collection and analysis of drug usage in an outpatient pharmacy. Presented at International Symposium on Clinical Pharmacy and Clinical Pharmacology, Boston, MA. Sponsored by the New England Medical Center. In Proceedings of Symposium on Clinical Pharmacy and Clinical Pharmacology. Published by No. Holland Press, Chapter 31, pp 399-406, 1976, September 19, 1975.
9. Leedom JM. Respiratory infections, etiology and anatomic correlations of the various respiratory syndromes in Proceedings of the Eisenhower Medical Center, No. 4. A Seminar on Infectious Diseases, Eisenhower Medical Center, Palm Desert, CA, pp 1018, December 5-6, 1975.
10. Underman AE, Overturf GD and Leedom JM. Bacterial Meningitis, Disease-a-Month 24(5)1-63, February 1978.
11. Leedom JM. Central nervous system infections, diagnosis and therapy. In Antibiotic Therapy - 11. Edited by Devetski RL, Notre Dame University Press, pp 91-110, 1978.
Editorial
1. Leedom JM, Wilkins JW, Portnoy B and Salvatore MA. Live rubella vaccine, established facts and extrapolations. LACMA Bulletin, pp 20-21, September 18, 1969.
2. Leedom JM. Commentary on Evaluation of Community-acquired pneumonia by Pennington JE. Patient Care 15:120-123, October 15, 1981.
Book Review
1. Leedom JM. Chemotherapy of Infection by William B. Pratt, pp 462 with illustrations. NY, Oxford U, Press, JAMA 239:2488, 1978.
2. Leedom JM. Current Clinical Topics in Infectious Diseases 3 by Jack S. Remington and Morton N. Swartz, pp 397 with illustrations. NY, McGraw-Hill Book Co., JAMA 249:2395-2397, 1983.
Miscellaneous Article
1. Wehrle PF, Leedom JM and Mathies AW, Mr. Treatment of meningococcal meningitis. Modern Treatment 4:929-938, No. 5, September 1967.
Non-Peer Review
1. Leedom JM and Yu V. Pneumonia in compromised patients. Patient Care 153-165, February 15, 1988.
Electronic Publication
1. Leedom JM. Milk of nonhuman origin and infectious diseases in humans. MDvista J of Med. Co-editor of Infectious Disease Jack S. Remington, 2001. www.Mdvista.com
Photos and Comments:
USC Memorial Service
July 13, 2008 Health Sciences Campus 3PM
This web site is authored by Liane Leedom, M.D. I am looking for input from friends and colleagues of my dad's. Please email me with comments and pictures to add to this site.
We ask that you remember Dr. Leedom by contributing to the memorial fund:
To contribute online click on this text.
Or send checks to:
John M. Leedom, M.D. Memorial Fund
Keck School of Medicine of USC
c/o: David Eshaghpour
1975 Zonal Avenue, Suite 300
Los Angeles, CA 90033-9026